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Alzheimer’s disease affects millions of people worldwide, and its diagnosis remains a challenge. Until now, doctors have relied on invasive procedures such as lumbar puncture or expensive techniques like brain imaging to confirm the presence of the disease. Today, a major breakthrough could change everything: blood markers now allow the disease to be detected with accuracy comparable to these traditional methods.<\/p>\n
Among these markers, a protein called tau phosphorylated at threonine 217, or p-tau217, stands out. It is released into the blood when characteristic Alzheimer’s lesions appear in the brain. Recent studies show that measuring its levels, alone or combined with another protein called amyloid-beta 42, can identify the disease with reliability close to 98%. This discovery paves the way for a more accessible, faster, and less burdensome diagnosis for patients.<\/p>\n
These blood tests are particularly useful for people with memory problems or signs of cognitive decline. They can confirm or rule out the presence of the disease, thus avoiding more invasive and costly examinations. However, their interpretation must take into account certain factors such as age or kidney function, which can influence the results. For example, in people over 80 years old or with kidney failure, the results may be less reliable and require additional tests.<\/p>\n
To ensure the quality of the analyses, strict protocols have been established. Blood samples must be taken under specific conditions: the blood is quickly centrifuged and stored at low temperatures to preserve the markers. Laboratories use automated platforms that provide reproducible and reliable results, essential for accurate diagnosis.<\/p>\n
The introduction of these tests into clinical practice marks an important step. They could facilitate access to early diagnosis, which is crucial for appropriate management. In Italy, recommendations have been developed to standardize their use, specifying when and how to prescribe them. These tests do not replace a complete clinical evaluation, but they offer a valuable alternative, especially in cases where other methods are not available or suitable.<\/p>\n
This innovation is part of a broader effort to improve the detection of Alzheimer’s disease. In the future, it could also help monitor the progression of the disease or the effectiveness of treatments. For now, their use focuses on patients with symptoms, but research is underway to assess their relevance in at-risk individuals before the onset of the first signs.<\/p>\n
These advances show how precision medicine is transforming the management of neurodegenerative diseases. By making diagnosis simpler and more accessible, these blood tests could change the lives of many patients and their families, while optimizing healthcare system resources.<\/p>\n
DOI:<\/strong> https:\/\/doi.org\/10.1007\/s10072-026-08931-7<\/a><\/p>\n Title:<\/strong> Blood-based biomarkers for Alzheimer\u2019s disease diagnosis: a joint position paper from the Italian Societies of Neurology (SIN) and of Clinical Biochemistry and Clinical Molecular Biology – Laboratory Medicine(SIBioC) and from the Autonomous Association affiliated with SIN for dementia (SINdem)<\/p>\n Journal:<\/strong> Neurological Sciences<\/p>\n Publisher:<\/strong> Springer Science and Business Media LLC<\/p>\n Authors:<\/strong> Lorenzo Gaetani; Luisa Agnello; Andrea Pilotto; Alberto Benussi; Annachiara Cagnin; Lucilla Parnetti; Marco Bozzali; Alessandro Padovani; Marcello Ciaccio; ; Marco Canevelli; Giordano Cecchetti; Giuseppe Di Fede; Giulia Giacomucci; Guido Maria Giuffr\u00e8; Piergiorgio Grillo; Daniele Imperiale; Camillo Marra; Alessandro Martorana; Federico Massa; Benedetta Nacmias; Federico Paolini Paoletti; Piero Parchi; Tommaso Piccoli; Domenico Plantone; Elisa Rubino; Martina Valletta; Gianluigi Zanusso; Laura Bonanni; ; Giulia Musso; Giulia Sancesario<\/p>\n","protected":false},"excerpt":{"rendered":" Can a Simple Blood Test Revolutionize Alzheimer’s Disease Diagnosis? Alzheimer’s disease affects millions of people worldwide, and its diagnosis remains a challenge. Until now, doctors have relied on invasive procedures such as lumbar puncture or expensive techniques like brain imaging to confirm the presence of the disease. Today, a major breakthrough could change everything: blood… Continue reading Can a Simple Blood Test Revolutionize Alzheimer’s Disease Diagnosis?<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[2,6],"tags":[],"class_list":["post-37","post","type-post","status-publish","format-standard","hentry","category-health","category-international","entry"],"_links":{"self":[{"href":"https:\/\/publichealthtribune.com\/en\/wp-json\/wp\/v2\/posts\/37","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/publichealthtribune.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/publichealthtribune.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/publichealthtribune.com\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/publichealthtribune.com\/en\/wp-json\/wp\/v2\/comments?post=37"}],"version-history":[{"count":1,"href":"https:\/\/publichealthtribune.com\/en\/wp-json\/wp\/v2\/posts\/37\/revisions"}],"predecessor-version":[{"id":38,"href":"https:\/\/publichealthtribune.com\/en\/wp-json\/wp\/v2\/posts\/37\/revisions\/38"}],"wp:attachment":[{"href":"https:\/\/publichealthtribune.com\/en\/wp-json\/wp\/v2\/media?parent=37"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/publichealthtribune.com\/en\/wp-json\/wp\/v2\/categories?post=37"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/publichealthtribune.com\/en\/wp-json\/wp\/v2\/tags?post=37"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}