{"id":19,"date":"2026-06-13T09:32:21","date_gmt":"2026-06-13T07:32:21","guid":{"rendered":"https:\/\/publichealthtribune.com\/vi\/2026\/06\/13\/khang-the-bao-ton-khoi-luong-co-bap-trong-qua-trinh-giam-can\/"},"modified":"2026-06-13T09:33:59","modified_gmt":"2026-06-13T07:33:59","slug":"khang-the-bao-ton-khoi-luong-co-bap-trong-qua-trinh-giam-can","status":"publish","type":"post","link":"https:\/\/publichealthtribune.com\/vi\/2026\/06\/13\/khang-the-bao-ton-khoi-luong-co-bap-trong-qua-trinh-giam-can\/","title":{"rendered":"Kh\u00e1ng th\u1ec3 b\u1ea3o t\u1ed3n kh\u1ed1i l\u01b0\u1ee3ng c\u01a1 b\u1eafp trong qu\u00e1 tr\u00ecnh gi\u1ea3m c\u00e2n"},"content":{"rendered":"

\"Kh\u00e1ng“`html<\/p>\n

Kh\u00e1ng th\u1ec3 b\u1ea3o t\u1ed3n kh\u1ed1i l\u01b0\u1ee3ng c\u01a1 b\u1eafp trong qu\u00e1 tr\u00ecnh gi\u1ea3m c\u00e2n<\/h1>\n

Gi\u1ea3m c\u00e2n do c\u00e1c ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb nh\u01b0 tirz\u00e9patide th\u01b0\u1eddng \u0111i k\u00e8m v\u1edbi s\u1ef1 suy gi\u1ea3m kh\u1ed1i l\u01b0\u1ee3ng c\u01a1 b\u1eafp, \u0111i\u1ec1u n\u00e0y c\u00f3 th\u1ec3 g\u00e2y h\u1ea1i cho s\u1ee9c kh\u1ecfe v\u00e0 ch\u1ee9c n\u0103ng th\u1ec3 ch\u1ea5t. M\u1ed9t nghi\u00ean c\u1ee9u g\u1ea7n \u0111\u00e2y \u0111\u00e3 \u0111\u00e1nh gi\u00e1 hi\u1ec7u qu\u1ea3 c\u1ee7a m\u1ed9t kh\u00e1ng th\u1ec3 g\u1ecdi l\u00e0 apitegromab trong vi\u1ec7c h\u1ea1n ch\u1ebf s\u1ef1 m\u1ea5t m\u00e1t c\u01a1 b\u1eafp n\u00e0y. Kh\u00e1ng th\u1ec3 n\u00e0y ho\u1ea1t \u0111\u1ed9ng b\u1eb1ng c\u00e1ch ch\u1eb7n \u0111\u1eb7c hi\u1ec7u s\u1ef1 k\u00edch ho\u1ea1t c\u1ee7a myostatin, m\u1ed9t protein \u0111i\u1ec1u ch\u1ec9nh s\u1ef1 ph\u00e2n h\u1ee7y c\u1ee7a c\u01a1 b\u1eafp. B\u1eb1ng c\u00e1ch \u1ee9c ch\u1ebf protein n\u00e0y, apitegromab th\u00fac \u0111\u1ea9y s\u1ef1 t\u0103ng tr\u01b0\u1edfng v\u00e0 b\u1ea3o t\u1ed3n kh\u1ed1i l\u01b0\u1ee3ng c\u01a1 b\u1eafp.<\/p>\n

Nghi\u00ean c\u1ee9u \u0111\u00e3 bao g\u1ed3m 102 ng\u01b0\u1eddi tr\u01b0\u1edfng th\u00e0nh th\u1eeba c\u00e2n ho\u1eb7c b\u00e9o ph\u00ec, \u0111\u01b0\u1ee3c chia th\u00e0nh hai nh\u00f3m: m\u1ed9t nh\u00f3m nh\u1eadn tirz\u00e9patide k\u1ebft h\u1ee3p v\u1edbi apitegromab, nh\u00f3m c\u00f2n l\u1ea1i nh\u1eadn tirz\u00e9patide c\u00f9ng v\u1edbi gi\u1ea3 d\u01b0\u1ee3c. Sau 24 tu\u1ea7n, nh\u1eefng ng\u01b0\u1eddi \u0111\u01b0\u1ee3c \u0111i\u1ec1u tr\u1ecb b\u1eb1ng apitegromab \u0111\u00e3 m\u1ea5t trung b\u00ecnh \u00edt h\u01a1n 1,9 kg kh\u1ed1i l\u01b0\u1ee3ng c\u01a1 b\u1eafp so v\u1edbi nh\u00f3m d\u00f9ng gi\u1ea3 d\u01b0\u1ee3c, trong khi t\u1ed5ng l\u01b0\u1ee3ng c\u00e2n n\u1eb7ng m\u1ea5t \u0111i l\u00e0 t\u01b0\u01a1ng t\u1ef1. \u0110i\u1ec1u n\u00e0y \u0111\u1ea1i di\u1ec7n cho vi\u1ec7c b\u1ea3o t\u1ed3n g\u1ea7n 55% kh\u1ed1i l\u01b0\u1ee3ng c\u01a1 b\u1eafp so v\u1edbi nh\u00f3m gi\u1ea3 d\u01b0\u1ee3c. N\u1ed3ng \u0111\u1ed9 apitegromab v\u00e0 myostatin ti\u1ec1m \u1ea9n \u0111\u00e3 t\u0103ng d\u1ea7n v\u00e0 \u0111\u1ea1t \u0111\u1ebfn ng\u01b0\u1ee1ng \u1ed5n \u0111\u1ecbnh sau kho\u1ea3ng 16 tu\u1ea7n, x\u00e1c nh\u1eadn hi\u1ec7u qu\u1ea3 c\u1ee7a ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb.<\/p>\n

C\u00e1c t\u00e1c d\u1ee5ng ph\u1ee5 \u1edf hai nh\u00f3m l\u00e0 t\u01b0\u01a1ng \u0111\u01b0\u01a1ng, ch\u1ee7 y\u1ebfu l\u00e0 nh\u1eb9 v\u00e0 t\u1ea1m th\u1eddi. Kh\u00f4ng c\u00f3 t\u00e1c d\u1ee5ng ph\u1ee5 nghi\u00eam tr\u1ecdng n\u00e0o li\u00ean quan \u0111\u1ebfn apitegromab \u0111\u01b0\u1ee3c b\u00e1o c\u00e1o. K\u1ebft qu\u1ea3 cho th\u1ea5y apitegromab, b\u1eb1ng c\u00e1ch nh\u1eafm m\u1ee5c ti\u00eau ch\u1ecdn l\u1ecdc v\u00e0o myostatin, cho ph\u00e9p b\u1ea3o t\u1ed3n kh\u1ed1i l\u01b0\u1ee3ng c\u01a1 b\u1eafp m\u00e0 kh\u00f4ng l\u00e0m \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn vi\u1ec7c gi\u1ea3m m\u1ee1, t\u1eeb \u0111\u00f3 mang l\u1ea1i m\u1ed9t ph\u01b0\u01a1ng ph\u00e1p \u0111\u1ea7y h\u1ee9a h\u1eb9n cho nh\u1eefng ng\u01b0\u1eddi \u0111ang \u0111i\u1ec1u tr\u1ecb b\u1ec7nh b\u00e9o ph\u00ec.<\/p>\n

Myostatin l\u00e0 m\u1ed9t protein t\u1ef1 nhi\u00ean gi\u1edbi h\u1ea1n s\u1ef1 ph\u00e1t tri\u1ec3n c\u1ee7a c\u01a1 b\u1eafp. Vi\u1ec7c \u1ee9c ch\u1ebf ch\u1ecdn l\u1ecdc myostatin b\u1edfi apitegromab tr\u01b0\u1edbc \u0111\u00e2y \u0111\u00e3 ch\u1ee9ng minh \u0111\u01b0\u1ee3c l\u1ee3i \u00edch trong c\u00e1c m\u00f4 h\u00ecnh \u0111\u1ed9ng v\u1eadt v\u00e0 \u1edf b\u1ec7nh nh\u00e2n m\u1eafc b\u1ec7nh teo c\u01a1 t\u1ee7y s\u1ed1ng, c\u1ee7ng c\u1ed1 th\u00eam ti\u1ec1m n\u0103ng \u0111i\u1ec1u tr\u1ecb c\u1ee7a n\u00f3. Nh\u1eefng ng\u01b0\u1eddi tham gia nghi\u00ean c\u1ee9u \u0111\u00e3 th\u1ea5y t\u1ef7 l\u1ec7 m\u1ea5t m\u1ee1 chi\u1ebfm ph\u1ea7n l\u1edbn h\u01a1n trong t\u1ed5ng l\u01b0\u1ee3ng c\u00e2n n\u1eb7ng m\u1ea5t \u0111i, \u0111i\u1ec1u n\u00e0y c\u00f3 l\u1ee3i cho s\u1ee9c kh\u1ecfe chuy\u1ec3n h\u00f3a.<\/p>\n

Nghi\u00ean c\u1ee9u n\u00e0y x\u00e1c nh\u1eadn r\u1eb1ng apitegromab, b\u1eb1ng c\u00e1ch t\u00e1c \u0111\u1ed9ng l\u00ean m\u1ed9t c\u01a1 ch\u1ebf sinh h\u1ecdc \u0111\u00e3 \u0111\u01b0\u1ee3c thi\u1ebft l\u1eadp, c\u00f3 th\u1ec3 l\u00e0m gi\u1ea3m s\u1ef1 m\u1ea5t m\u00e1t c\u01a1 b\u1eafp li\u00ean quan \u0111\u1ebfn c\u00e1c ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb gi\u1ea3m c\u00e2n, \u0111\u1ed3ng th\u1eddi duy tr\u00ec \u0111\u01b0\u1ee3c s\u1ef1 dung n\u1ea1p t\u1ed1t. K\u1ebft qu\u1ea3 m\u1edf ra con \u0111\u01b0\u1eddng cho c\u00e1c chi\u1ebfn l\u01b0\u1ee3c m\u1edbi nh\u1eb1m c\u1ea3i thi\u1ec7n th\u00e0nh ph\u1ea7n c\u01a1 th\u1ec3 trong c\u00e1c ch\u1ebf \u0111\u1ed9 \u0111i\u1ec1u tr\u1ecb b\u1eb1ng thu\u1ed1c.<\/p>\n

“`<\/p>\n

\n

\u00c0 propos de nos sources<\/h2>\n

Publication originale<\/h3>\n

DOI\u00a0:<\/strong> https:\/\/doi.org\/10.1038\/s41591-026-04440-4<\/a><\/p>\n

Titre\u00a0:<\/strong> Apitegromab for lean mass preservation during tirzepatide-induced weight loss: a randomized, double-blind, placebo-controlled phase 2 trial<\/p>\n

Revue : <\/strong> Nature Medicine<\/p>\n

\u00c9diteur : <\/strong> Springer Science and Business Media LLC<\/p>\n

Auteurs : <\/strong> Richard E. Pratley; Douglas Scott Denham; Rupal Trivedi; Elaine Watkins; Lisa Connery; Jennifer Barnes; Dongzi Yu; Janet Hong; Christopher Simard; Kimberly Umans; Lan Liu; Giridhar S. Tirucherai; Jing L. Marantz<\/p>\n","protected":false},"excerpt":{"rendered":"

“`html Kh\u00e1ng th\u1ec3 b\u1ea3o t\u1ed3n kh\u1ed1i l\u01b0\u1ee3ng c\u01a1 b\u1eafp trong qu\u00e1 tr\u00ecnh gi\u1ea3m c\u00e2n Gi\u1ea3m c\u00e2n do c\u00e1c ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb nh\u01b0 tirz\u00e9patide th\u01b0\u1eddng \u0111i k\u00e8m v\u1edbi s\u1ef1 suy gi\u1ea3m kh\u1ed1i l\u01b0\u1ee3ng c\u01a1 b\u1eafp, \u0111i\u1ec1u n\u00e0y c\u00f3 th\u1ec3 g\u00e2y h\u1ea1i cho s\u1ee9c kh\u1ecfe v\u00e0 ch\u1ee9c n\u0103ng th\u1ec3 ch\u1ea5t. M\u1ed9t nghi\u00ean c\u1ee9u g\u1ea7n \u0111\u00e2y \u0111\u00e3… Continue reading Kh\u00e1ng th\u1ec3 b\u1ea3o t\u1ed3n kh\u1ed1i l\u01b0\u1ee3ng c\u01a1 b\u1eafp trong qu\u00e1 tr\u00ecnh gi\u1ea3m c\u00e2n<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[2],"tags":[],"class_list":["post-19","post","type-post","status-publish","format-standard","hentry","category-suc-khoe","entry"],"_links":{"self":[{"href":"https:\/\/publichealthtribune.com\/vi\/wp-json\/wp\/v2\/posts\/19","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/publichealthtribune.com\/vi\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/publichealthtribune.com\/vi\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/publichealthtribune.com\/vi\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/publichealthtribune.com\/vi\/wp-json\/wp\/v2\/comments?post=19"}],"version-history":[{"count":1,"href":"https:\/\/publichealthtribune.com\/vi\/wp-json\/wp\/v2\/posts\/19\/revisions"}],"predecessor-version":[{"id":20,"href":"https:\/\/publichealthtribune.com\/vi\/wp-json\/wp\/v2\/posts\/19\/revisions\/20"}],"wp:attachment":[{"href":"https:\/\/publichealthtribune.com\/vi\/wp-json\/wp\/v2\/media?parent=19"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/publichealthtribune.com\/vi\/wp-json\/wp\/v2\/categories?post=19"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/publichealthtribune.com\/vi\/wp-json\/wp\/v2\/tags?post=19"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}